Seraphina was born in San Gimignano, Italy, to a poor family. She was known for her self denial and acts of penance as a young girl. A mysterious illness left this beautiful girl unattractive; her eyes, feet, and hands became deformed and eventually Seraphina was paralyzed.
Her mother and father both died while she was young. She was devoted to St. Gregory the Great. She died on the feast of St. Gregory, exactly as she had been warned by Gregory in a dream. Seraphina was a very helpful child around the family home. She did many of the chores and helped her mother spin and sew.
Her feast day is March 12.